IMLred

Consulting Services

Development and Implementation

Leading the fight against tuberculosis through cutting-edge research and global collaboration.

Development and Implementation

of TB Laboratory Diagnostic Algorithms and National TB Laboratory Policies

WHO-recommended diagnostic algorithms need to be tailored for specific country in order to address country diagnostic landscape, epidemiology, resistance prevalence and resource availability. Well-structured diagnostic algorithms, aligned with WHO-endorsed techniques, streamline patient pathways, ensure timely and accurate detection, and enable appropriate treatment initiation.

National TB laboratory policies further provide a standardized framework, ensuring consistency and quality across diagnostic networks, providing necessary link between laboratory and clinicians.

Approach:

By integrating evidence-based algorithms and robust policies, we enhance the effectiveness and efficiency of TB laboratory services, ensuring timely and accurate diagnosis, reduced diagnostic delays, and improved patient outcomes.

This is achieved though:

Situational Analysis and Policy Review
  • Comprehensive review of existing diagnostic workflows, laboratory capacities, and epidemiological contexts.
  • Assessment of gaps in current algorithms and laboratory practices.
Algorithm Customization and Development
  • Designing diagnostic algorithms tailored to national needs, integrating WHO-recommended tests
    (e.g., microscopy, culture, GeneXpert, Line Probe Assays, and advanced molecular techniques such as tNGS).
  • Ensuring algorithms address multi-drug-resistant (MDR) and extensively drug-resistant (XDR) TB detection requirements.
Technical Validation and Pilot Testing
  • Conducting validation studies to ensure the reliability, accuracy, and feasibility of the algorithms.
  • Piloting the algorithms in selected laboratories to refine processes before nationwide rollout.
Capacity Building and Training
  • Delivering practical, hands-on training for laboratory personnel on algorithm implementation.
  • Providing step-by-step guidance on integrating algorithms into routine diagnostic workflows.
Monitoring and Evaluation:
  • Establishing systems for continuous quality assurance (QA) and performance monitoring.
  • Conducting periodic reviews to assess the impact and suggest refinements.

Service Packages offered:

Development and Implementation

Algorithm Design and Validation

End-to-end development of diagnostic algorithms, from gap analysis to WHO-compliant design and validation.
Development and Implementation

Policy Development

Drafting or updating National TB Laboratory Policies to reflect the latest diagnostic advancements and WHO guidelines.
Development and Implementation

Implementation Support

On-site technical support during pilot phases and full-scale implementation.
Development and Implementation

Training and Capacity Building

Interactive workshops and mentorship programs for laboratory staff and policymakers.

Development and Implementation

Quality Assurance and Monitoring

Establishing QA mechanisms, including periodic on-site visits, performance audits, and corrective action plans
Development and Implementation

Integration of Advanced Diagnostics

Assistance in incorporating cutting-edge technologies like tNGS into existing diagnostic frameworks.

Past Experience:

Our team has extensive expertise in developing and implementing TB laboratory diagnostic algorithms and policies in diverse settings, improving diagnostic outcomes and operational efficiency.

Examples include:

Tajikistan
2020, 2022, 2023
Several redactions of National Laboratory Diagnostic algorithm
Kyrgyzstan
2013
Tailoring diagnostic workflows to high-burden, resource-limited settings and ensuring alignment with international standards in middle-income countries
Uzbekistan
…

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For inquiries or more information, please reach out to us at:

+49 89 1259996-0

info@imlred.de

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